SIN3A

SIN3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PO4
Identifiers
Aliases	SIN3A, Paired amphipathic helix protein Sin3a
External IDs	MGI: 107157 HomoloGene: 32124 GeneCards: SIN3A
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription corepressor activity • transcription corepressor activity • histone deacetylase activity • transcription factor activity, sequence-specific DNA binding • protein complex binding • protein deacetylase activity • transcription factor binding • chromatin binding • transcription regulatory region sequence-specific DNA binding • RNA polymerase II activating transcription factor binding • protein binding • RNA polymerase II repressing transcription factor binding • RNA binding Cellular component • transcription factor complex • transcriptional repressor complex • Sin3 complex • nucleoplasm • protein complex • nucleolus • chromatin • nucleus • kinetochore Biological process • negative regulation of protein localization to nucleus • regulation of transcription, DNA-templated • cellular lipid metabolic process • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • rhythmic process • cellular response to dopamine • response to methylglyoxal • negative regulation of circadian rhythm • regulation of hormone levels • aging • negative regulation of apoptotic process • in utero embryonic development • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • protein deacetylation • DNA replication • cellular protein localization • negative regulation of transcription regulatory region DNA binding • response to organonitrogen compound • hematopoietic progenitor cell differentiation • activation of innate immune response • positive regulation of G2/M transition of mitotic cell cycle • negative regulation of transcription, DNA-templated • histone deacetylation • positive regulation of chromatin silencing • negative regulation of histone H3-K27 acetylation • cellular response to glucose stimulus • positive regulation of transcription from RNA polymerase II promoter • positive regulation of defense response to virus by host Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25942	20466
Ensembl	ENSG00000169375	ENSMUSG00000042557
UniProt	Q96ST3	Q60520
RefSeq (mRNA)	NM_001145357 NM_001145358 NM_015477	NM_001110350 NM_001110351 NM_011378
RefSeq (protein)	NP_001138829 NP_001138830 NP_056292	NP_001103820.1 NP_001103821.1 NP_035508.2 NP_001103820 NP_001103821 NP_035508
Location (UCSC)	Chr 15: 75.37 – 75.46 Mb	Chr 9: 57.07 – 57.13 Mb
PubMed search

1PO4

25942

20466

ENSG00000169375

ENSMUSG00000042557

Q96ST3

Q60520

NM_001145357
NM_001145358
NM_015477

NM_001110350
NM_001110351
NM_011378

NP_001138829
NP_001138830
NP_056292

NP_035508

Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene.

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.

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Wikipedia