SHP-1

PTPN6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ

Identifiers

Aliases

PTPN6, HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, protein tyrosine phosphatase, non-receptor type 6

External IDs

MGI: 96055 HomoloGene: 56589 GeneCards: PTPN6

Gene ontology
Molecular function	• phosphoprotein phosphatase activity • SH3 domain binding • phosphatase activity • phosphotyrosine residue binding • SH2 domain binding • protein binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity • protein kinase binding • cell adhesion molecule binding
Cellular component	• cytoplasm • cytosol • membrane • cell-cell junction • alpha-beta T cell receptor complex • nucleolus • extracellular exosome • nucleus • extracellular region • specific granule lumen • tertiary granule lumen
Biological process	• B cell receptor signaling pathway • megakaryocyte development • G-protein coupled receptor signaling pathway • cell differentiation • GO:0007242 intracellular signal transduction • regulation of release of sequestered calcium ion into cytosol • abortive mitotic cell cycle • T cell costimulation • protein dephosphorylation • platelet formation • negative regulation of T cell receptor signaling pathway • platelet activation • negative regulation of humoral immune response mediated by circulating immunoglobulin • regulation of G1/S transition of mitotic cell cycle • negative regulation of T cell proliferation • regulation of type I interferon-mediated signaling pathway • negative regulation of peptidyl-tyrosine phosphorylation • negative regulation of MAP kinase activity • hematopoietic progenitor cell differentiation • positive regulation of cell proliferation • negative regulation of MAPK cascade • regulation of ERK1 and ERK2 cascade • negative regulation of B cell receptor signaling pathway • peptidyl-tyrosine phosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of cell adhesion mediated by integrin • cell proliferation • platelet aggregation • regulation of B cell differentiation • leukocyte migration • natural killer cell mediated cytotoxicity • negative regulation of cell proliferation • dephosphorylation • apoptotic process • peptidyl-tyrosine dephosphorylation • neutrophil degranulation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5777


15170

Ensembl


ENSG00000111679


ENSMUSG00000004266

UniProt


P29350


P29351

RefSeq (mRNA)


NM_002831 NM_080548 NM_080549


NM_001077705 NM_013545

RefSeq (protein)


NP_002822 NP_536858 NP_536859


NP_001071173.1 NP_038573.2 NP_001071173 NP_038573

Location (UCSC)

Chr 12: 6.95 – 6.96 Mb

Chr 6: 124.72 – 124.74 Mb

PubMed search

1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ

NM_002831
NM_080548
NM_080549

NM_001077705
NM_013545

...
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