SHC1

SHC1

Protein SHC1 PDB 1mil.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI

Identifiers

SHC1, SHC, SHCA, SHC adaptor protein 1

External IDs

MGI: 98296 HomoloGene: 7934 GeneCards: SHC1

Gene ontology
Molecular function	• insulin-like growth factor receptor binding • transmembrane receptor protein tyrosine kinase adaptor activity • insulin receptor binding • neurotrophin TRKA receptor binding • ephrin receptor binding • epidermal growth factor receptor binding • receptor tyrosine kinase binding • protein binding • phospholipid binding • Ras guanyl-nucleotide exchange factor activity • epidermal growth factor binding
Cellular component	• cytoplasm • cytosol • mitochondrial matrix • mitochondrion • Shc-EGFR complex • plasma membrane
Biological process	• actin cytoskeleton reorganization • insulin receptor signaling pathway • single organismal cell-cell adhesion • intracellular signal transduction • epidermal growth factor receptor signaling pathway • cellular response to growth factor stimulus • MAPK cascade • Fc-epsilon receptor signaling pathway • positive regulation of DNA replication • heart development • IRE1-mediated unfolded protein response • activation of MAPK activity • regulation of cell proliferation • angiogenesis • positive regulation of cell proliferation • regulation of epidermal growth factor-activated receptor activity • regulation of growth • Ras protein signal transduction • viral process • leukocyte migration • signal transduction • positive regulation of GTPase activity • ERBB2 signaling pathway • axon guidance
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE SHC1 201469 s at tn.png

PBB GE SHC1 214853 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


6464


20416


ENSG00000160691


ENSMUSG00000042626


P29353


P98083

RefSeq (mRNA)


NM_001130040 NM_001130041 NM_001202859 NM_003029 NM_183001


NM_001113331 NM_011368

RefSeq (protein)


NP_001123512 NP_001123513 NP_001189788 NP_003020 NP_892113


NP_001106802.1 NP_035498.2 NP_001106802 NP_035498

Location (UCSC)

Chr 1: 154.96 – 154.97 Mb

Chr 3: 89.42 – 89.43 Mb

PubMed search

1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI

ENSG00000160691

ENSMUSG00000042626

NM_001130040
NM_001130041
NM_001202859
NM_003029
NM_183001

NM_001113331
NM_011368

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Wikipedia

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