SEMA7A

SEMA7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NVQ
Identifiers
Aliases	SEMA7A, CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL, semaphorin 7A (John Milton Hagen blood group)
External IDs	MGI: 1306826 HomoloGene: 2678 GeneCards: SEMA7A
Gene ontology Molecular function • protein binding • integrin binding • neuropilin binding Cellular component • membrane • plasma membrane • anchored component of membrane • extracellular space • external side of plasma membrane Biological process • cell differentiation • positive regulation of protein phosphorylation • nervous system development • multicellular organism development • osteoblast differentiation • immune response • positive regulation of ERK1 and ERK2 cascade • axon extension • olfactory lobe development • integrin-mediated signaling pathway • positive regulation of axon extension • inflammatory response • neuron projection development • regulation of inflammatory response • negative chemotaxis • positive regulation of macrophage cytokine production Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8482	20361
Ensembl	ENSG00000138623	ENSMUSG00000038264
UniProt	O75326	Q9QUR8
RefSeq (mRNA)	NM_003612 NM_001146029 NM_001146030	NM_011352
RefSeq (protein)	NP_001139501 NP_001139502 NP_003603	NP_035482
Location (UCSC)	Chr 15: 74.41 – 74.43 Mb	Chr 9: 57.94 – 57.96 Mb
PubMed search

3NVQ

8482

20361

ENSG00000138623

ENSMUSG00000038264

O75326

Q9QUR8

NM_003612
NM_001146029
NM_001146030

NM_011352

NP_001139501
NP_001139502
NP_003603

NP_035482

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM]

This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

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Wikipedia