SEMA5A

SEMA5A
Identifiers
Aliases	SEMA5A, SEMAF, semF, semaphorin 5A
External IDs	MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Gene ontology Molecular function • chondroitin sulfate proteoglycan binding • heparan sulfate proteoglycan binding • syndecan binding • semaphorin receptor binding • neuropilin binding Cellular component • membrane • plasma membrane • extracellular exosome • integral component of membrane • extracellular space Biological process • negative regulation of endothelial cell apoptotic process • negative regulation of cell adhesion • cell differentiation • positive regulation of protein kinase B signaling • positive regulation of endothelial cell proliferation • positive regulation of catenin import into nucleus • positive regulation of endothelial cell chemotaxis • cell-cell signaling • positive regulation of axon extension involved in axon guidance • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • nervous system development • positive regulation of angiogenesis • multicellular organism development • diencephalon development • cell adhesion • signal clustering • cell chemotaxis • positive chemotaxis • axonal fasciculation • positive regulation of actin filament depolymerization • negative regulation of axon extension involved in axon guidance • negative chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9037	20356
Ensembl	ENSG00000112902	ENSMUSG00000022231
UniProt	Q13591	Q62217 Q3UPZ0
RefSeq (mRNA)	NM_003966	NM_009154
RefSeq (protein)	NP_003957	NP_033180
Location (UCSC)	Chr 5: 9.04 – 9.55 Mb	Chr 15: 32.24 – 32.7 Mb
PubMed search

9037

20356

ENSG00000112902

ENSMUSG00000022231

Q13591

Q62217
Q3UPZ0

NM_003966

NM_009154

NP_003957

NP_033180

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

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Wikipedia