SEMA3A

SEMA3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q47, 4GZ8, 4GZA
Identifiers
Aliases	SEMA3A, COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1, semaphorin 3A
External IDs	MGI: 107558 HomoloGene: 31358 GeneCards: SEMA3A
Genetically Related Diseases
Obesity, prion disease, attention deficit hyperactivity disorder
Gene ontology Molecular function • chemorepellent activity • semaphorin receptor binding • neuropilin binding Cellular component • extracellular region • dendrite • extracellular space • axon Biological process • sympathetic ganglion development • negative regulation of axon extension • cell differentiation • ventral trunk neural crest cell migration • regulation of axon extension involved in axon guidance • semaphorin-plexin signaling pathway involved in neuron projection guidance • negative chemotaxis • neural crest cell migration involved in sympathetic nervous system development • sympathetic nervous system development • facioacoustic ganglion development • dendrite morphogenesis • trigeminal ganglion development • neuron migration • semaphorin-plexin signaling pathway involved in axon guidance • regulation of heart rate • nervous system development • axon guidance • multicellular organism development • sympathetic neuron projection guidance • neural crest cell migration involved in autonomic nervous system development • branchiomotor neuron axon guidance • gonadotrophin-releasing hormone neuronal migration to the hypothalamus • axonogenesis involved in innervation • dichotomous subdivision of terminal units involved in salivary gland branching • facial nerve structural organization • olfactory bulb development • motor neuron axon guidance • axonal fasciculation • negative regulation of epithelial cell migration • nerve development • trigeminal nerve structural organization • axon extension involved in axon guidance • semaphorin-plexin signaling pathway • sympathetic neuron projection extension • positive regulation of male gonad development • sensory system development • apoptotic process • negative regulation of neuron projection development • negative regulation of axon extension involved in axon guidance • positive regulation of neuron migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10371	20346
Ensembl	ENSG00000075213	ENSMUSG00000028883
UniProt	Q14563	O08665
RefSeq (mRNA)	NM_006080	NM_001243072 NM_001243073 NM_009152
RefSeq (protein)	NP_006071	NP_001230001.1 NP_001230002.1 NP_033178.2 NP_001230001 NP_001230002 NP_033178
Location (UCSC)	Chr 7: 83.96 – 84.49 Mb	Chr 5: 13.13 – 13.6 Mb
PubMed search

1Q47, 4GZ8, 4GZA

10371

20346

ENSG00000075213

ENSMUSG00000028883

Q14563

O08665

NM_006080

NM_001243072
NM_001243073
NM_009152

NP_006071

NP_033178

Semaphorin-3A is a protein that in humans is encoded by the SEMA3A gene.

The SEMA3A gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted Sema3A protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development.

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Wikipedia