SECISBP2

SECISBP2
Identifiers
Aliases	SECISBP2, SBP2, SECIS binding protein 2
External IDs	MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.2 Start 89,318,506 bp End 89,359,662 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A5 Start 51,651,697 bp End 51,684,044 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • mRNA 3'-UTR binding • protein binding • RNA binding • selenocysteine insertion sequence binding • ribonucleoprotein complex binding Cellular component • nucleus • mitochondrion • intracellular ribonucleoprotein complex Biological process • translation • striatum development • neuron development • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • selenocysteine incorporation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79048	75420
Ensembl	ENSG00000187742	ENSMUSG00000035139
UniProt	Q96T21	n/a
RefSeq (mRNA)	NM_001282688 NM_001282689 NM_001282690 NM_024077 NM_001354696 NM_001354697 NM_001354698 NM_001354702	NM_029279 NM_001308448
RefSeq (protein)	NP_001269617 NP_001269618 NP_001269619 NP_076982 NP_001341625 NP_001341626 NP_001341627 NP_001341631	n/a
Location (UCSC)	Chr 9: 89.32 – 89.36 Mb	Chr 9: 51.65 – 51.68 Mb
PubMed search

79048

75420

ENSG00000187742

ENSMUSG00000035139

Q96T21

n/a

NM_001354697
NM_001354698
NM_001354702

NM_029279
NM_001308448

NP_001341626
NP_001341627
NP_001341631

n/a

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

...
Wikipedia