SDC4

SDC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EJP, 1EJQ, 1OBY, 1YBO
Identifiers
Aliases	SDC4, SYND4, syndecan 4
External IDs	MGI: 1349164 HomoloGene: 31121 GeneCards: SDC4
Gene ontology Molecular function • fibronectin binding • protein binding • thrombospondin receptor activity • protein kinase C binding Cellular component • integral component of membrane • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • extracellular region • lysosomal lumen • Golgi lumen • membrane raft • costamere • extracellular exosome • cell surface Biological process • glycosaminoglycan metabolic process • ureteric bud development • inner ear receptor stereocilium organization • positive regulation of extracellular exosome assembly • wound healing • retinoid metabolic process • neural tube closure • glycosaminoglycan catabolic process • glycosaminoglycan biosynthetic process • positive regulation of focal adhesion assembly • positive regulation of exosomal secretion • regulation of fibroblast migration • positive regulation of stress fiber assembly • positive regulation of protein kinase activity • signal transduction • negative regulation of T cell proliferation • leukocyte migration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6385	20971
Ensembl	ENSG00000124145	ENSMUSG00000017009
UniProt	P31431	O35988
RefSeq (mRNA)	NM_002999	NM_011521
RefSeq (protein)	NP_002990	NP_035651.1 NP_035651
Location (UCSC)	Chr 20: 45.33 – 45.35 Mb	Chr 2: 164.42 – 164.44 Mb
PubMed search

1EJP, 1EJQ, 1OBY, 1YBO

6385

20971

ENSG00000124145

ENSMUSG00000017009

P31431

O35988

NM_002999

NM_011521

NP_002990

NP_035651.1
NP_035651

Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. Syndecans are the best-characterized plasma membrane proteoglycans. Their intracellular domain of membrane-spanning core protein interacts with actin cytoskeleton and signaling molecules in the cell cortex. Syndecans are normally found on the cell surface of fibroblasts and epithelial cells. Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules.

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