SCN5A

SCN5A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN
Identifiers
Aliases	SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5
External IDs	OMIM: 600163 MGI: 98251 HomoloGene: 22738 GeneCards: SCN5A
Targeted by Drug
aconitine, lidocaine
Gene ontology Molecular function • nitric-oxide synthase binding • ion channel binding • protein domain specific binding • voltage-gated sodium channel activity involved in AV node cell action potential • voltage-gated sodium channel activity involved in bundle of His cell action potential • sodium channel activity • voltage-gated sodium channel activity involved in SA node cell action potential • voltage-gated ion channel activity • ion channel activity • voltage-gated sodium channel activity involved in Purkinje myocyte action potential • protein binding • ankyrin binding • enzyme binding • fibroblast growth factor binding • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • scaffold protein binding • protein kinase binding • ubiquitin protein ligase binding • voltage-gated sodium channel activity • calmodulin binding Cellular component • voltage-gated sodium channel complex • integral component of membrane • lateral plasma membrane • membrane • intercalated disc • T-tubule • intracellular • cell surface • Z disc • endoplasmic reticulum • caveola • sarcolemma • plasma membrane Biological process • regulation of atrial cardiac muscle cell membrane repolarization • cellular response to calcium ion • membrane depolarization during AV node cell action potential • regulation of ventricular cardiac muscle cell membrane depolarization • membrane depolarization during Purkinje myocyte cell action potential • membrane depolarization during bundle of His cell action potential • membrane depolarization during action potential • cardiac muscle contraction • sodium ion transmembrane transport • sodium ion transport • positive regulation of epithelial cell proliferation • SA node cell action potential • brainstem development • cardiac ventricle development • regulation of atrial cardiac muscle cell membrane depolarization • membrane depolarization • ventricular cardiac muscle cell action potential • bundle of His cell action potential • cardiac muscle cell action potential involved in contraction • regulation of ion transmembrane transport • ion transport • cerebellum development • regulation of heart rate • odontogenesis of dentin-containing tooth • positive regulation of action potential • regulation of cardiac muscle cell contraction • telencephalon development • AV node cell to bundle of His cell communication • cardiac conduction • transmembrane transport • positive regulation of sodium ion transport • transport • membrane depolarization during SA node cell action potential • response to denervation involved in regulation of muscle adaptation • regulation of sodium ion transmembrane transport • AV node cell action potential • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • neuronal action potential • regulation of ventricular cardiac muscle cell membrane repolarization • regulation of postsynaptic membrane potential • atrial cardiac muscle cell action potential • membrane depolarization during atrial cardiac muscle cell action potential Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6331	20271
Ensembl	ENSG00000183873	ENSMUSG00000032511
UniProt	Q14524	Q9JJV9
RefSeq (mRNA)	NM_000335 NM_001099404 NM_001099405 NM_001160160 NM_001160161 NM_198056	NM_001253860 NM_021544
RefSeq (protein)	NP_000326 NP_001092874 NP_001092875 NP_001153632 NP_001153633 NP_932173	NP_001240789.1 NP_067519.2 NP_001240789 NP_067519
Location (UCSC)	Chr 3: 38.55 – 38.65 Mb	Chr 9: 119.48 – 119.58 Mb
PubMed search

2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN

6331

20271

ENSG00000183873

ENSMUSG00000032511

Q14524

Q9JJV9

NM_198056

NM_001253860
NM_021544

NP_932173

NP_001240789.1
NP_067519.2
NP_001240789
NP_067519

Na_V1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Na_V1.5 is found primarily in cardiac muscle, where it mediates the fast influx of Na⁺-ions (I_Na) across the cell membrane, resulting in the fast depolarization phase of the cardiac action potential. As such, it plays a major role in impulse propagation through the heart. A vast number of cardiac diseases is associated with mutations in Na_V1.5 (see paragraph genetics). SCN5A is the gene that encodes the cardiac sodium channel Na_V1.5.

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