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SCN5A

SCN5A
Protein SCN5A PDB 1byy.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1, sodium voltage-gated channel alpha subunit 5
External IDs OMIM: 600163 MGI: 98251 HomoloGene: 22738 GeneCards: SCN5A
Targeted by Drug
aconitine, lidocaine
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253860
NM_021544

RefSeq (protein)

NP_001240789.1
NP_067519.2
NP_001240789
NP_067519

Location (UCSC) Chr 3: 38.55 – 38.65 Mb Chr 9: 119.48 – 119.58 Mb
PubMed search

2KBI, 2L53, 4DCK, 4DJC, 4JQ0, 4OVN

NM_198056

NM_001253860
NM_021544

NP_932173

NP_001240789.1
NP_067519.2
NP_001240789
NP_067519

NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. NaV1.5 is found primarily in cardiac muscle, where it mediates the fast influx of Na+-ions (INa) across the cell membrane, resulting in the fast depolarization phase of the cardiac action potential. As such, it plays a major role in impulse propagation through the heart. A vast number of cardiac diseases is associated with mutations in NaV1.5 (see paragraph genetics). SCN5A is the gene that encodes the cardiac sodium channel NaV1.5.


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