SCN3B

SCN3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L1D
Identifiers
Aliases	SCN3B, ATFB16, BRGDA7, HSA243396, SCNB3, sodium voltage-gated channel beta subunit 3
External IDs	MGI: 1918882 HomoloGene: 10176 GeneCards: SCN3B
Gene ontology Molecular function • sodium channel regulator activity • ion channel binding • sodium channel activity • voltage-gated ion channel activity • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • integral component of membrane • membrane • plasma membrane • Z disc Biological process • regulation of ventricular cardiac muscle cell membrane depolarization • membrane depolarization during action potential • cardiac muscle contraction • sodium ion transmembrane transport • sodium ion transport • SA node cell action potential • regulation of atrial cardiac muscle cell membrane depolarization • membrane depolarization • ventricular cardiac muscle cell action potential • regulation of ion transmembrane transport • cardiac muscle cell action potential involved in contraction • ion transport • nervous system development • positive regulation of heart rate • cardiac conduction • regulation of sodium ion transmembrane transporter activity • atrial cardiac muscle cell action potential • positive regulation of sodium ion transport • transport • sensory perception of pain • protein localization to plasma membrane • regulation of heart rate by cardiac conduction • membrane depolarization during cardiac muscle cell action potential • regulation of postsynaptic membrane potential • regulation of molecular function Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55800	235281
Ensembl	ENSG00000166257	ENSMUSG00000049281
UniProt	Q9NY72	Q8BHK2
RefSeq (mRNA)	NM_001040151 NM_018400	NM_001083917 NM_001286614 NM_153522 NM_178227
RefSeq (protein)	NP_001035241 NP_060870	NP_001077386.1 NP_001273543.1 NP_839941.1 NP_001077386 NP_001273543 NP_839941
Location (UCSC)	Chr 11: 123.63 – 123.66 Mb	Chr 9: 40.27 – 40.29 Mb
PubMed search

4L1D

55800

235281

ENSG00000166257

ENSMUSG00000049281

Q9NY72

Q8BHK2

NM_001040151
NM_018400

NM_001083917
NM_001286614
NM_153522
NM_178227

NP_001035241
NP_060870

NP_839941

Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene. Two alternatively spliced variants, encoding the same protein, have been identified.

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel.

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Wikipedia