SCN2A

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2KAV, 4JPZ

Identifiers

Aliases

SCN2A, BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2, sodium voltage-gated channel alpha subunit 2

External IDs

MGI: 98248 HomoloGene: 75001 GeneCards: SCN2A

Gene ontology
Molecular function	• sodium channel activity • voltage-gated ion channel activity • ion channel activity • voltage-gated sodium channel activity
Cellular component	• voltage-gated sodium channel complex • integral component of membrane • membrane • intrinsic component of plasma membrane • sodium channel complex • plasma membrane • node of Ranvier • integral component of plasma membrane • intracellular • intercalated disc • T-tubule • axon • paranode region of axon
Biological process	• membrane depolarization during action potential • sodium ion transport • regulation of ion transmembrane transport • ion transport • transmembrane transport • transport • myelination • neuronal action potential • regulation of postsynaptic membrane potential • sodium ion transmembrane transport • nervous system development • intrinsic apoptotic signaling pathway in response to osmotic stress • neuron apoptotic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6326


110876

Ensembl


ENSG00000136531


ENSMUSG00000075318

UniProt


Q99250


n/a

RefSeq (mRNA)


NM_001040142 NM_001040143 NM_021007


NM_001099298 NM_001346679 NM_001346680

RefSeq (protein)


NP_001035232 NP_001035233 NP_066287


n/a

Location (UCSC)

Chr 2: 165.24 – 165.39 Mb

Chr 2: 65.62 – 65.77 Mb

PubMed search

n/a

NM_001040142
NM_001040143
NM_021007

NM_001099298
NM_001346679
NM_001346680

NP_001035232
NP_001035233
NP_066287

n/a

Na_vα1.2, also known as the sodium channel, voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the SCN2A gene. Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain the Na_vα1.2 subunit are called Na_v1.2 channels.

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