SCN1B

SCN1B
Identifiers
Aliases	SCN1B, ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1
External IDs	MGI: 98247 HomoloGene: 810 GeneCards: SCN1B
Gene ontology Molecular function • sodium channel activity • voltage-gated ion channel activity • voltage-gated sodium channel activity involved in Purkinje myocyte action potential • voltage-gated sodium channel activity involved in cardiac muscle cell action potential • voltage-gated sodium channel activity • sodium channel regulator activity • sodium channel inhibitor activity • protein binding Cellular component • integral component of membrane • membrane • sodium channel complex • extracellular region • voltage-gated sodium channel complex • node of Ranvier • intercalated disc • T-tubule • plasma membrane Biological process • membrane depolarization during Purkinje myocyte cell action potential • cardiac muscle contraction • regulation of sodium ion transport • sodium ion transport • regulation of atrial cardiac muscle cell membrane depolarization • membrane depolarization • regulation of ion transmembrane transport • cardiac muscle cell action potential involved in contraction • ion transport • cell adhesion • regulation of sodium ion transmembrane transporter activity • positive regulation of sodium ion transport • transport • response to pyrethroid • regulation of heart rate by cardiac conduction • chemical synaptic transmission • corticospinal neuron axon guidance • neuronal action potential propagation • axon guidance • cardiac conduction • regulation of ventricular cardiac muscle cell membrane repolarization • sodium ion transmembrane transport • locomotion • positive regulation of neuron projection development • regulation of postsynaptic membrane potential • membrane depolarization during cardiac muscle cell action potential Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6324	20266
Ensembl	ENSG00000105711	ENSMUSG00000019194
UniProt	Q07699	P97952
RefSeq (mRNA)	NM_001037 NM_199037 NM_001321605	NM_011322
RefSeq (protein)	NP_001028 NP_001308534 NP_950238	NP_035452.1 NP_035452
Location (UCSC)	Chr 19: 35.03 – 35.04 Mb	Chr 7: 31.12 – 31.13 Mb
PubMed search

6324

20266

ENSG00000105711

ENSMUSG00000019194

Q07699

P97952

NM_001037
NM_199037
NM_001321605

NM_011322

NP_001028
NP_001308534
NP_950238

NP_035452.1
NP_035452

Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.

Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM]

Mutation in the SCN1B gene are associated with disorders such as Brugada syndrome and GEFS.

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Wikipedia