SCARB2

SCARB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW2
Identifiers
Aliases	SCARB2, AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII, scavenger receptor class B member 2
External IDs	MGI: 1196458 HomoloGene: 48353 GeneCards: SCARB2
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.1 Start 76,158,733 bp End 76,234,536 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E2 Start 92,441,314 bp End 92,506,833 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • enzyme binding • protein binding • virus receptor activity • receptor activity Cellular component • integral component of membrane • lysosome • lysosomal lumen • extracellular exosome • membrane • focal adhesion • lysosomal membrane • plasma membrane • clathrin-coated vesicle membrane • late endosome membrane Biological process • viral entry into host cell • protein targeting to lysosome • viral process • positive regulation of neuron projection development • membrane organization • regulation of endosome organization • regulation of glucosylceramidase activity • regulation of lysosome organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	950	12492
Ensembl	ENSG00000138760	ENSMUSG00000029426
UniProt	Q14108	O35114
RefSeq (mRNA)	NM_005506 NM_001204255	NM_007644
RefSeq (protein)	NP_001191184 NP_005497	NP_031670
Location (UCSC)	Chr 4: 76.16 – 76.23 Mb	Chr 4: 92.44 – 92.51 Mb
PubMed search

4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW2

950

12492

ENSG00000138760

ENSMUSG00000029426

Q14108

O35114

NM_005506
NM_001204255

NM_007644

NP_001191184
NP_005497

NP_031670

Lysosome membrane protein 2 (LIMP-2) is a protein that in humans is encoded by the SCARB2 gene. LIMP-2 is expressed in brain, heart, liver, lung and kidney, mainly in the membrane of lysosome organelles; however, in cardiac muscle, LIMP-2 is also expressed at intercalated discs. LIMP-2 in a membrane protein in lysosomes that functions to regulate lysosomal/endosomal transport. Mutations in LIMP-2 have been shown to cause Gaucher disease, myoclonic epilepsy, and action myoclonus renal failure syndrome. Abnormal levels of LIMP-2 have also been found in patients with hypertrophic cardiomyopathy.

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Wikipedia