SCARB1

SCARB1
Identifiers
Aliases	SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, scavenger receptor class B member 1
External IDs	MGI: 893578 HomoloGene: 21132 GeneCards: SCARB1
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 124,776,856 bp End 124,882,668 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 64.11 cM|5 G1.1 Start 125,277,087 bp End 125,341,094 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • apolipoprotein binding • protein homodimerization activity • virus receptor activity • transporter activity • high-density lipoprotein particle receptor activity • phosphatidylserine binding • apolipoprotein A-I binding • lipopolysaccharide binding • low-density lipoprotein particle binding • 1-phosphatidylinositol binding • protein binding • high-density lipoprotein particle binding • lipopolysaccharide receptor activity Cellular component • cytoplasm • integral component of membrane • endocytic vesicle membrane • intracellular membrane-bounded organelle • membrane • plasma membrane • integral component of plasma membrane • cell surface • lysosomal membrane • caveola • extracellular exosome • microvillus membrane Biological process • cholesterol import • positive regulation of triglyceride biosynthetic process • regulation of phosphatidylcholine catabolic process • recognition of apoptotic cell • lipid transport • low-density lipoprotein particle clearance • blood vessel endothelial cell migration • positive regulation of cholesterol storage • phospholipid transport • cholesterol transport • wound healing • cholesterol catabolic process • receptor-mediated endocytosis • high-density lipoprotein particle remodeling • positive regulation of endothelial cell migration • androgen biosynthetic process • vitamin transmembrane transport • positive regulation of nitric-oxide synthase activity • endothelial cell proliferation • lipopolysaccharide transport • cholesterol efflux • phagocytosis, recognition • viral entry into host cell • intestinal absorption • cholesterol homeostasis • regulation of phagocytosis • adhesion of symbiont to host • viral process • detection of lipopolysaccharide • triglyceride homeostasis • reverse cholesterol transport • lipopolysaccharide-mediated signaling pathway • high-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	949	20778
Ensembl	ENSG00000073060	ENSMUSG00000037936
UniProt	Q8WTV0	Q61009
RefSeq (mRNA)	NM_005505 NM_001082959	NM_001205082 NM_001205083 NM_016741
RefSeq (protein)	NP_001076428 NP_005496	NP_001192011 NP_001192012 NP_058021
Location (UCSC)	Chr 12: 124.78 – 124.88 Mb	Chr 12: 125.28 – 125.34 Mb
PubMed search

949

20778

ENSG00000073060

ENSMUSG00000037936

Q8WTV0

Q61009

NM_005505
NM_001082959

NM_001205082
NM_001205083
NM_016741

NP_001076428
NP_005496

NP_001192011
NP_001192012
NP_058021

Scavenger receptor class B member 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene. SR-BI functions as a receptor for high-density lipoprotein.

Scavenger receptor class B, type I (SR-BI) is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. It is best known for its role in facilitating the uptake of cholesteryl esters from high-density lipoproteins in the liver. This process drives the movement of cholesterol from peripheral tissues towards the liver, where cholesterol can either be secreted via the bile duct or be used to synthesise steroid hormones. This movement of cholesterol is known as reverse cholesterol transport and is a protective mechanism against the development of atherosclerosis, which is the principal cause of heart disease and stroke.

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Wikipedia