SAMHD1

SAMHD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR, 4RXS, 4TNP, 4TNQ, 4TNR, 4TNX, 4TNY, 4TNZ, 4TO0, 4TO1, 4TO2, 4TO3, 4TO4, 4TO5, 4TO6, 4ZWE, 4ZWG, 5AO4, 5AO1, 5AO0, 5AO2, 5AO3
Identifiers
Aliases	SAMHD1, CHBL2, DCIP, HDDC1, MOP-5, SBBI88, SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
External IDs	MGI: 1927468 HomoloGene: 9160 GeneCards: SAMHD1
Gene ontology Molecular function • zinc ion binding • metal ion binding • protein binding • catalytic activity • dGTP binding • RNA binding • nucleic acid binding • dGTPase activity • hydrolase activity • ribonuclease activity Cellular component • plasma membrane • intracellular • nucleoplasm • nucleus Biological process • regulation of innate immune response • immune system process • dATP catabolic process • dGTP catabolic process • defense response to virus • type I interferon signaling pathway • immune response • metabolic process • innate immune response • protein homotetramerization • RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25939	56045
Ensembl	ENSG00000101347	ENSMUSG00000027639
UniProt	Q9Y3Z3	Q60710
RefSeq (mRNA)	NM_015474	NM_001139520 NM_018851
RefSeq (protein)	NP_056289	NP_001132992.1 NP_061339.3 NP_001132992 NP_061339
Location (UCSC)	Chr 20: 36.89 – 36.95 Mb	Chr 2: 157.1 – 157.14 Mb
PubMed search

2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR, 4RXS, 4TNP, 4TNQ, 4TNR, 4TNX, 4TNY, 4TNZ, 4TO0, 4TO1, 4TO2, 4TO3, 4TO4, 4TO5, 4TO6, 4ZWE, 4ZWG, 5AO4, 5AO1, 5AO0, 5AO2, 5AO3

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