SAG (gene)

SAG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZWJ
Identifiers
Aliases	SAG, RP47, S-AG, S-antigen; retina and pineal gland (arrestin)
External IDs	MGI: 98227 HomoloGene: 455 GeneCards: SAG
Gene ontology Molecular function • protein phosphatase inhibitor activity • phosphoprotein binding • opsin binding Cellular component • cytosol • photoreceptor outer segment • photoreceptor inner segment Biological process • rhodopsin mediated signaling pathway • regulation of rhodopsin mediated signaling pathway • visual perception • signal transduction • response to stimulus • cell surface receptor signaling pathway • negative regulation of catalytic activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6295	20215
Ensembl	n/a	ENSMUSG00000056055
UniProt	P10523	P20443
RefSeq (mRNA)	NM_000541	NM_009118
RefSeq (protein)	NP_000532	NP_033144.1 NP_033144
Location (UCSC)	Chr 2: 233.31 – 233.35 Mb	Chr 1: 87.8 – 87.85 Mb
PubMed search

4ZWJ

6295

20215

n/a

ENSMUSG00000056055

P10523

P20443

NM_000541

NM_009118

NP_000532

NP_033144.1
NP_033144

S-arrestin is a protein that in humans is encoded by the SAG gene.

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness.

...
Wikipedia