SAFB

SAFB
Identifiers
Aliases	SAFB, HAP, HET, SAF-B1, SAFB1, SAB-B1, SAF-B, scaffold attachment factor B
External IDs	MGI: 2146974 HomoloGene: 2229 GeneCards: SAFB
Gene ontology Molecular function • DNA binding • core promoter binding • chromatin binding • protein binding • nucleic acid binding • double-stranded DNA binding • sequence-specific DNA binding • RNA binding Cellular component • nucleoplasm • nucleus Biological process • regulation of transcription, DNA-templated • chromatin organization • transcription, DNA-templated • hormone metabolic process • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • intracellular estrogen receptor signaling pathway • regulation of mRNA processing • growth Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6294	224903
Ensembl	ENSG00000160633	ENSMUSG00000071054
UniProt	Q15424	D3YXK2
RefSeq (mRNA)	NM_001201338 NM_001201339 NM_001201340 NM_002967 NM_001320571 NM_001320572	NM_001163300
RefSeq (protein)	NP_001188267 NP_001188268 NP_001188269 NP_001307500 NP_001307501 NP_002958	NP_001156772
Location (UCSC)	Chr 19: 5.62 – 5.67 Mb	Chr 17: 56.58 – 56.61 Mb
PubMed search

6294

224903

ENSG00000160633

ENSMUSG00000071054

Q15424

D3YXK2

NM_001320572

NM_001163300

NP_002958

NP_001156772

Scaffold attachment factor B, also known as SAFB, is a gene with homologs that have been studied in humans and mice.

This gene encodes a DNA-binding protein that has specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there are conflicting views as to whether this protein is a component of chromatin, the nuclear matrix, or both. Scaffold attachment factors are a subset of nuclear matrix proteins (NMP) with enriched binding to AT-rich S/MAR sequences. The SAF-B protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.

SAFB has been shown to interact with:

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Wikipedia