SAA1

SAA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IP8, 4IP9
Identifiers
Aliases	SAA1, PIG4, SAA, SAA2, TP53I4, Serum amyloid A1
External IDs	MGI: 98221 HomoloGene: 128033 GeneCards: SAA1
Gene ontology Molecular function • heparin binding • chemoattractant activity • G-protein coupled receptor binding Cellular component • endocytic vesicle lumen • extracellular region • high-density lipoprotein particle • cytoplasmic microtubule • extracellular exosome • extracellular space Biological process • cellular protein metabolic process • positive regulation of cytosolic calcium ion concentration • positive regulation of cytokine secretion • receptor-mediated endocytosis • neutrophil chemotaxis • platelet activation • macrophage chemotaxis • activation of MAPK activity • acute-phase response • positive regulation of interleukin-1 secretion • lymphocyte chemotaxis • innate immune response • negative regulation of inflammatory response • positive regulation of cell adhesion • regulation of protein secretion • positive chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6288	20208
Ensembl	ENSG00000173432	ENSMUSG00000074115
UniProt	P0DJI8	P05366
RefSeq (mRNA)	NM_199161 NM_000331 NM_001178006	NM_009117
RefSeq (protein)	NP_000322 NP_001171477 NP_954630	NP_033143.1 NP_033143
Location (UCSC)	Chr 11: 18.27 – 18.27 Mb	Chr 7: 46.74 – 46.74 Mb
PubMed search

4IP8, 4IP9

6288

20208

ENSG00000173432

ENSMUSG00000074115

P0DJI8

P05366

NM_199161
NM_000331
NM_001178006

NM_009117

NP_000322
NP_001171477
NP_954630

NP_033143.1
NP_033143

Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis.

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Wikipedia