S1PR3

S1PR3
Identifiers
Aliases	S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	MGI: 1339365 HomoloGene: 3829 GeneCards: S1PR3
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.1 Start 88,991,447 bp End 89,005,010 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A5 Start 51,408,639 bp End 51,422,797 bp
Gene ontology Molecular function • signal transducer activity • lipid binding • integrin binding • sphingosine-1-phosphate receptor activity • G-protein coupled receptor activity • protein binding Cellular component • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane Biological process • Notch signaling pathway • signal transduction • anatomical structure morphogenesis • positive regulation of cytosolic calcium ion concentration • G-protein coupled receptor signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • negative regulation of establishment of endothelial barrier • positive regulation of cell proliferation • sphingosine-1-phosphate signaling pathway • regulation of interleukin-1 beta production • cytokine production • inflammatory response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1903	13610
Ensembl	ENSG00000213694	ENSMUSG00000067586
UniProt	Q99500	Q9Z0U9
RefSeq (mRNA)	NM_005226	NM_010101
RefSeq (protein)	NP_005217	NP_034231
Location (UCSC)	Chr 9: 88.99 – 89.01 Mb	Chr 9: 51.41 – 51.42 Mb
PubMed search

1903

13610

ENSG00000213694

ENSMUSG00000067586

Q99500

Q9Z0U9

NM_005226

NM_010101

NP_005217

NP_034231

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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