S1PR1

S1PR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V2W, 3V2Y
Identifiers
Aliases	S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
External IDs	MGI: 1096355 HomoloGene: 1071 GeneCards: S1PR1
Gene ontology Molecular function • sphingolipid binding • sphingosine-1-phosphate receptor activity • G-protein coupled receptor activity • signal transducer activity • G-protein coupled receptor binding Cellular component • integral component of membrane • endosome • membrane • intrinsic component of plasma membrane • plasma membrane • membrane raft • external side of plasma membrane • nucleoplasm • intracellular membrane-bounded organelle Biological process • actin cytoskeleton reorganization • T cell migration • G-protein coupled receptor signaling pathway • heart trabecula morphogenesis • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • sphingosine-1-phosphate signaling pathway • positive regulation of cell migration • regulation of bone mineralization • transmission of nerve impulse • chemotaxis • positive regulation of positive chemotaxis • positive regulation of GTPase activity • brain development • regulation of cell adhesion • cell adhesion • angiogenesis • neuron differentiation • positive regulation of cell proliferation • endothelial cell differentiation • negative regulation of stress fiber assembly • regulation of bone resorption • cell migration • signal transduction • lamellipodium assembly • positive regulation of transcription from RNA polymerase II promoter • cardiac muscle tissue growth involved in heart morphogenesis • positive regulation of smooth muscle cell proliferation • blood vessel maturation • leukocyte chemotaxis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1901	13609
Ensembl	ENSG00000170989	ENSMUSG00000045092
UniProt	P21453	O08530
RefSeq (mRNA)	NM_001400 NM_001320730	NM_007901
RefSeq (protein)	NP_001307659 NP_001391	NP_031927
Location (UCSC)	Chr 1: 101.24 – 101.24 Mb	Chr 3: 115.71 – 115.72 Mb
PubMed search

3V2W, 3V2Y

1901

13609

ENSG00000170989

ENSMUSG00000045092

P21453

O08530

NM_001400
NM_001320730

NM_007901

NP_001307659
NP_001391

NP_031927

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.

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