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S1PR1

S1PR1
3v2y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
External IDs MGI: 1096355 HomoloGene: 1071 GeneCards: S1PR1
RNA expression pattern
PBB GE EDG1 204642 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001400
NM_001320730

NM_007901

RefSeq (protein)

NP_001307659
NP_001391

NP_031927

Location (UCSC) Chr 1: 101.24 – 101.24 Mb Chr 3: 115.71 – 115.72 Mb
PubMed search

3V2W, 3V2Y

NM_001400
NM_001320730

NM_007901

NP_001307659
NP_001391

NP_031927

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1P1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.


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Wikipedia

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