Route 5 (Missouri)
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| Route information | ||||
| Maintained by MoDOT | ||||
| Length: | 354.9 mi (571.2 km) | |||
| Existed: | 1922 – present | |||
| Major junctions | ||||
| South end: |
 AR 5 at the Arkansas state line |
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 US 160 in Gainesville US 60 in Mansfield I-44 in Lebanon US 54 in Camdenton I-70 in Boonville US 24 in Keytesville  US 36 / Route 110 between Laclede and Marceline US 136 in Unionville
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| North end: |
 Iowa 5 at the Iowa state line |
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| Highway system | ||||
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Missouri Route 5 is the longest state highway in Missouri and the only Missouri state highway to traverse the entire state. It is part of a three state, 650 mile highway 5. To the north, it continues into Iowa as Iowa Highway 5 and to the south it enters Arkansas as Highway 5. With only a few exceptions, it is two-lane for its entire length. Business Route 5 serves Milan and Ava.
Route 5 begins at the Arkansas state line in Ozark County as a continuation of Arkansas Highway 5. Approximately 8.5 miles (13.7 km) to the north of the state line, Route 5 meets U.S. 160 after which it forms a 6.2 mi (10.0 km) east-west concurrency to the east where it enters Gainesville. After leaving its U.S. 160 concurrency to the north, Route 5 continues northwest for approximately 13.2 mi (21.2 km) before forming a 3.3 mi (5.3 km) north-south wrong-way concurrency with Route 95 into Wasola. Route 5 enters Douglas County 0.6 mi (0.97 km) north of Wasola.
Thirteen miles into Douglas County, Route 5 forms a four-mile north-south concurrency with Route 76 past Ava, and serves the town itself with a business route. Within the northwest part of Ava, the concurrent routes intersect Route 14. After Route 76 leaves the concurrency to the east, Route 5 continues for 10 miles before entering Wright County.
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