Route 22 (Missouri)
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| Route information | ||||
| Maintained by MoDOT | ||||
| Length: | 23 mi (37 km) | |||
| Existed: | 1922 – present | |||
| Major junctions | ||||
| East end: |
 Route 15 in Mexico
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| West end: |
  US 63/Route F south of Clark
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Route 22 is a highway in central Missouri. Its eastern terminus is at Route 15 in Mexico; its western terminus is at U.S. Route 63 south of Clark on the Randolph/Boone county line. Route 22 was one of the original 1922 state highways and originally had an eastern terminus at Route 9 (now U.S. Route 61) in Louisiana. This section was replaced by U.S. Route 54 in 1926.
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