Robert Isaac Wilberforce (19 December 1802 – 3 February 1857) was an English clergyman and writer.
He was second son of abolitionist William Wilberforce, and active in the Oxford Movement. He was educated at Oriel College, Oxford, taking a double first in 1823.
In 1826, he was chosen fellow of Oriel and was ordained, among his friends and colleagues being Newman, Pusey and Keble. For a few years he was one of the tutors at Oriel. The provost Edward Hawkins disliked his religious views, and in 1831 Wilberforce resigned and left Oxford. In 1832 he obtained the living of East Farleigh, Kent, which in 1840 he exchanged for that of Burton Agnes, near Hull.
In 1841, he was appointed archdeacon of the East Riding of Yorkshire. About this time Wilberforce became close with Henry Manning, and they exchanged many letters on theological and ecclesiastical questions. They were deeply involved in re-examining the relationship between the Church of England and Roman Catholicism. On 27 March 1848, Robert Wilberforce and his brother Samuel joined the Canterbury Association.
In 1851, Manning joined the Roman Catholic Church, and three years later Wilberforce took the same step. His conversion came as a reaction to the so-called Gorham Judgement. He was preparing for his (Roman Catholic) ordination when he died at Albano on 3 February 1857. He is buried in Rome at the Basilica of Santa Maria sopra Minerva, near the Pantheon. His tomb is situated just outside the right transept of the church.