Rheb

RHEB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XTQ, 1XTR, 1XTS, 3SEA, 3T5G
Identifiers
Aliases	RHEB, RHEB2, Ras homolog enriched in brain
External IDs	MGI: 97912 HomoloGene: 123916 GeneCards: RHEB
Gene ontology Molecular function • nucleotide binding • GTP binding • metal ion binding • protein binding • GTPase activity • protein kinase binding Cellular component • cytoplasm • cytosol • Golgi apparatus • endoplasmic reticulum membrane • membrane • Golgi membrane • lysosomal membrane • endoplasmic reticulum • spliceosomal complex • extracellular exosome • endomembrane system Biological process • positive regulation of oligodendrocyte differentiation • regulation of TOR signaling • small GTPase mediated signal transduction • regulation of type B pancreatic cell development • cell cycle arrest • macroautophagy • positive regulation of TOR signaling • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6009	19744
Ensembl	ENSG00000106615	ENSMUSG00000028945
UniProt	Q15382	Q921J2
RefSeq (mRNA)	NM_005614	NM_053075
RefSeq (protein)	NP_005605	NP_444305.2 NP_444305
Location (UCSC)	Chr 7: 151.47 – 151.52 Mb	Chr 5: 24.8 – 24.84 Mb
PubMed search

1XTQ, 1XTR, 1XTS, 3SEA, 3T5G

6009

19744

ENSG00000106615

ENSMUSG00000028945

Q15382

Q921J2

NM_005614

NM_053075

NP_005605

NP_444305.2
NP_444305

RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.

RHEB is a recently discovered member of the Ras superfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human carcinomas. For this reason, ways to inhibit RHEB to control the mTOR pathway are studied as possible treatments for uncontrollable tumor cell growth in several diseases, especially in tuberous sclerosis.

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Wikipedia