Rh-EPO

EPO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BUY, 1CN4, 1EER
Identifiers
Aliases	EPO, EP, MVCD2, erythropoietin, Erythropoietin
External IDs	OMIM: 133170 MGI: 95407 HomoloGene: 624 GeneCards: EPO
Gene ontology Molecular function • hormone activity • protein kinase activator activity • protein binding • erythropoietin receptor binding Cellular component • extracellular region • cell surface • cell body • extracellular space Biological process • erythrocyte maturation • negative regulation of cation channel activity • response to interleukin-1 • response to hypoxia • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to nutrient • response to salt stress • negative regulation of erythrocyte apoptotic process • response to testosterone • regulation of transcription from RNA polymerase II promoter • response to hyperoxia • positive regulation of Ras protein signal transduction • aging • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • response to electrical stimulus • blood circulation • response to estrogen • cellular hyperosmotic response • positive regulation of transcription, DNA-templated • positive regulation of DNA replication • response to vitamin A • response to lipopolysaccharide • acute-phase response • peptidyl-serine phosphorylation • response to axon injury • hemoglobin biosynthetic process • positive regulation of neuron differentiation • positive regulation of cell proliferation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of ERK1 and ERK2 cascade • positive regulation of neuron projection development • negative regulation of calcium ion transport into cytosol • negative regulation of myeloid cell apoptotic process • activation of protein kinase activity • embryo implantation • signal transduction • positive regulation of activated T cell proliferation • positive regulation of protein kinase activity • negative regulation of neuron death • apoptotic process • response to dexamethasone • cell proliferation • erythrocyte differentiation • erythropoietin-mediated signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2056	13856
Ensembl	ENSG00000130427	ENSMUSG00000029711
UniProt	P01588	P07321
RefSeq (mRNA)	NM_000799	NM_007942 NM_001312875
RefSeq (protein)	NP_000790	NP_001299804 NP_031968
Location (UCSC)	Chr 7: 100.72 – 100.72 Mb	Chr 5: 137.48 – 137.53 Mb
PubMed search

1BUY, 1CN4, 1EER

2056

13856

ENSG00000130427

ENSMUSG00000029711

P01588

P07321

NM_000799

NM_007942
NM_001312875

NP_000790

NP_001299804
NP_031968

Erythropoietin (EPO), also known as hematopoietin or hemopoietin, is a glycoprotein that controls erythropoiesis, or red blood cell production. It is a cytokine (protein signaling molecule) for erythrocyte (red blood cell) precursors in the bone marrow. Human EPO has a molecular weight of 34 kDa.

Erythropoietin is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and proximal convoluted tubule. It is also produced in perisinusoidal cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood. It is pronounced (/ɪˌrɪθroʊˈpɔɪᵻtən/ or /ɪˌrɪθroʊpoʊˈɛtɪn, -rə-, -ˈiː-, -tən/.)

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