"Rescue Me" is a song by American singer and songwriter Madonna from her first greatest hits compilation The Immaculate Collection (1990). It was written by Madonna and Shep Pettibone, who also worked with her on the worldwide chart-topping single "Vogue" (1990) as well as her fifth studio album Erotica (1992). Sire Records released "Rescue Me" as the second single from The Immaculate Collection on February 12, 1991, and as the third single on April 7 in the United Kingdom. It peaked in the top-five in countries such as Ireland, the UK, Italy, and South Africa, and at number nine on the US Billboard Hot 100.

"Rescue Me" was one of two newly released songs on The Immaculate Collection, the other being "Justify My Love". In the United States, it was released as the second single on February 12, 1991, and as the third single on April 7 in the United Kingdom, due to a remix of "Crazy for You" (1985) representing as the second single from the collection. It debuted on the Billboard Hot 100 the week of March 2, 1991 at number fifteen, becoming highest-debuting single on the chart by a female artist at the time.

"Rescue Me" is an upbeat dance-pop and house track; its composition is similar to that of "Vogue" (1990). According to sheet music published at Musicnotes.com at Alfred Publishing, the song is composed in the key of D-flat major, with Madonna's vocals ranging from B♭₃ to E♭₅. It is set in the time signature of common time and has a tempo of 116 beats per minute. Lyrically, "Rescue Me" expresses the extinguishing of deranged behavior in a relationship.

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