The Regional District of Mount Waddington (RDMW) is a regional district in British Columbia. It takes in the lower Central Coast region centred on the Queen Charlotte Strait coast of northern Vancouver Island and the adjoining parts of mainland British Columbia. It has a total land area of 20,288.4 km² (7,833.4 sq mi) and a 2006 census population of 11,651 persons, most of which is in towns on Vancouver Island and adjoining islands. The administrative centre is in the town of Port McNeill. Other municipalities include the district municipality of Port Hardy, the village of Port Alice, and the village of Alert Bay.
The region is named for Mount Waddington, which lies on its northeastern boundary and is the highest peak entirely within British Columbia (Fairweather Mountain, on the Alaska boundary, is the highest). Also within the regional district is Mount Silverthrone, the highest volcano in Canada, located in the remote Ha-Iltzuk Icefield. The eastern land boundary of the regional district is largely the divide of the Coast Mountains, inland from which is the Chilcotin District, which is part of the Cariboo Regional District. The northern land boundary with the Central Coast Regional District follows a watershed boundary, separating streams that flow into Queen Charlotte Sound north of Cape Caution from those that flow into the Sound to the south or that flow into Queen Charlotte Strait.