Reelin

RELN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2ddu, 2e26, 2DDU, 2E26, 3A7Q

Identifiers

RELN, LIS2, PRO1598, RL, reelin, ETL7

External IDs

OMIM: 600514 MGI: 103022 HomoloGene: 3699 GeneCards: RELN

Genetically Related Diseases

Alzheimer's disease, otosclerosis, multiple sclerosis, schizophrenia

Gene ontology
Molecular function	• metal ion binding • protein serine/threonine/tyrosine kinase activity • peptidase activity • hydrolase activity • serine-type peptidase activity • lipoprotein particle receptor binding • very-low-density lipoprotein particle receptor binding
Cellular component	• proteinaceous extracellular matrix • cytoplasm • dendrite • plasma membrane • extracellular region • extracellular space • membrane
Biological process	• NMDA glutamate receptor clustering • positive regulation of lateral motor column neuron migration • dendrite development • proteolysis • cerebral cortex development • lateral motor column neuron migration • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of TOR signaling • long-term memory • multicellular organism development • receptor localization to synapse • postsynaptic density protein 95 clustering • ventral spinal cord development • protein localization to synapse • forebrain development • long-term synaptic potentiation • regulation of gene expression • layer formation in cerebral cortex • cell migration • learning • associative learning • cell adhesion • hippocampus development • spinal cord patterning • cerebral cortex tangential migration • axon guidance • positive regulation of peptidyl-tyrosine phosphorylation • glial cell differentiation • peptidyl-tyrosine phosphorylation • positive regulation of excitatory postsynaptic potential • positive regulation of CREB transcription factor activity • positive regulation of protein kinase activity • modulation of synaptic transmission • positive regulation of AMPA receptor activity • brain development • central nervous system development • response to pain • positive regulation of synapse maturation • positive regulation of long-term synaptic potentiation • cell morphogenesis involved in differentiation • neuron migration • positive regulation of neuron projection development • positive regulation of small GTPase mediated signal transduction • positive regulation of synaptic transmission, glutamatergic • regulation of behavior • positive regulation of dendritic spine morphogenesis • reelin-mediated signaling pathway • regulation of NMDA receptor activity • positive regulation of protein tyrosine kinase activity
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE RELN 205923 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


5649


19699


ENSG00000189056


ENSMUSG00000042453


P78509


Q60841

RefSeq (mRNA)


NM_173054 NM_005045


NM_011261 NM_001310464

RefSeq (protein)


NP_005036 NP_774959


NP_035391.2 NP_001297393.1 NP_001297393 NP_035391

Location (UCSC)

Chr 7: 103.47 – 103.99 Mb

Chr 5: 21.88 – 22.34 Mb

PubMed search

2ddu, 2e26, 2DDU, 2E26, 3A7Q

ENSG00000189056

ENSMUSG00000042453

NM_173054
NM_005045

NM_011261
NM_001310464

NP_005036
NP_774959

NP_035391.2
NP_001297393.1
NP_001297393
NP_035391

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Wikipedia

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