"Red Nation" is a song by American rapper and West Coast hip hop artist Game featuring vocals from rapper Lil Wayne, from his anticipated fourth studio album The R.E.D. Album. Released as the album's lead single on April 12, 2011, the song was written by Game and Lil Wayne, and it was produced by Miami-based production duo Cool & Dre, noted for producing three of Game's singles including the 2005 smash hit single "Hate It or Love It" which featured vocals from former fellow G-Unit member rapper 50 Cent. The single also marks the second collaboration between Game and Lil Wayne, their first collaboration being on Game's 2008 international hit single "My Life" from his third studio album LAX (2008), which featured vocals from Lil Wayne during the song's chorus. The song features a music sample of the nightclub hit "Kernkraft 400" (2000) (German for "Nuclear Energy 400") performed by German techno and electro band Zombie Nation from their debut album Leichenschmaus (1999).

The song's sample of Kernkraft 400 by Zombie Nation is considered one of the most famous songs of electronic dance music and a tune often played at sporting events. The single was also thought to be and mark Game's first song to be released back under the Aftermath Entertainment and Interscope Records labels, the two record labels that released his debut studio album The Documentary (2005), after resigning back with Interscope Records back in 2009 later resigning back with Aftermath Entertainment in early 2010, and before a beef with former fellow G-Unit labelmate and group member 50 Cent caused him to release his two following albums and singles on Geffen Records, but this was proved untrue. On March 10, 2011 Game sent the single to Hip hop DJ Funkmaster Flex whom premiered it on his popular radio show on WQHT Hot 97 in New York City, New York. The song was well received by listeners unlike his previous four released singles.

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