"Real Muthaphuckkin G's" (alternatively and cleanly known as "Real Compton City G's") is a 1993 song by West Coast rapper Eazy-E from his EP It's On (Dr. Dre) 187um Killa. It is a diss track directed at former N.W.A bandmate Dr. Dre and his protégé Snoop Doggy Dogg. "Real Muthaphuckkin G's" peaked at #42 on the U.S. Billboard Hot 100 chart, becoming Eazy-E's highest charting single as a solo artist. "Real Muthaphuckkin G's" debuts brothers B.G. Knocc Out and Dresta, protégés of Eazy-E.

In 1991, Dr. Dre left N.W.A and formed Death Row with Suge Knight, releasing The Chronic with heavy support from up and coming rapper Snoop Doggy Dogg. With the success of The Chronic Dr. Dre had successfully re-branded himself as a part of the new wave of Gangsta Rappers while simultaneously popularizing a new G-Funk style of production which Dr. Dre had been experimenting with during his tenure with N.W.A. On one of The Chronic's singles, "Fuck Wit Dre Day (And Everybody's Celebratin')", Dr. Dre and Snoop Dogg insulted Eazy-E.

"Real Muthaphuckkin G's" was Eazy-E's response to "Fuck Wit Dre Day (And Everybody's Celebratin')" and the general success of Dr. Dre's newfound image on The Chronic. Lyrically Eazy-E questioned Dr. Dre's sexuality and credibility as a Gangsta for having worn androgynous clothing and makeup while a member of the World Class Wrecking Cru. On the track Eazy-E also ridiculed Dr. Dre for beating women, likely referencing Dr. Dre's 1991 assault of Dee Barnes. In the song's lyrics Eazy-E refers to the 1992 single 'Fuck Wit Dre Day' as "Eazy's pay day" as Dr. Dre's contract allowing him to move from Eazy-E's Ruthless to Suge Knight's Death Row Records granted Eazy-E retention of a portion of Dr. Dre's royalties. Lastly, the track also contained a subtle diss to Death Row CEO Suge Knight a known strongman with a well documented history of criminal intimidation and violence, whom Eazy-E calls Dr. Dre's "sergeant" and refers to Death Row as a "boot camp".

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