The single was released in 1994 as the follow-up to the popular "Real Muthaphuckkin G's" and was written by Eazy-E, Dirty Red and produced by Above the Law's Cold 187 um. Any Last Werdz did find some success on the charts, making it to #69 on the Hot R&B/Hip-Hop Songs and #5 on the Hot Rap Singles.

The song was released with a music video directed by Edward Louderback, whilst primary cinematography was handled by Richard Henkels. The duo had both just graduated from the Art Center College of Design and used Border Films as the production company. In the video, Eazy-E kills somebody, and is seen at his death bed with graphic images seen throughout the video to visualize the pain with any last words or thoughts compelled in the last moments of his life as seen at his death. Also throughout the video, you can see members of Bone Thugs-n-Harmony (Layzie Bone, Krayzie Bone, Bizzy Bone, Wish Bone, and Flesh-n-Bone), Cold 187 um, Kokane, Toker, and Dirty Red in the back. Upon its release, Eazy-E was in agreement with Louderback that rap videos should have more artistic value that wasn't at all, or rarely seen, in 1994. This led to the prevalence of more creativity in rap videos. This ended up being the last complete video finished by Eazy-E before his death, and has since become a cult classic.

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