Radicofani is a comune in the Province of Siena in the Italian region Tuscany, located in the natural park of Val D' Orcia about 110 kilometres (68 mi) southeast of Florence and about 60 kilometres (37 mi) southeast of Siena. As of 31 December 2012, it had a population of 1,148 and an area of 118.3 square kilometres (45.7 sq mi).
Radicofani borders the following municipalities: Abbadia San Salvatore, Castiglione d'Orcia, Pienza, San Casciano dei Bagni, Sarteano.
The main landmark of Radicofani is its Rocca (Castle), of Carolingian origin and documented since 978 as Castle of Ghino di Tacco. Occupying the highest point of a hill, at 896 metres (2,940 ft), it was restored after the conquest from the Grand Duchy of Tuscany (1560–67). It has two lines of walls: the external one has a pentagonal shape, while the inner one is triangular, with three ruined towers at each corner and a cassero (donjon) which can be visited.
Also notable is the Romanesque church of San Pietro, with a nave, housing some works by Andrea della Robbia, Benedetto Buglioni and Santi Buglioni. Also by della Robbia is the precious Madonna with Saints at the high altar of the church of Sant'Agata
Climate is characterized by relatively high temperatures and evenly distributed precipitation throughout the year. The Köppen Climate Classification subtype for this climate is Cfa (Humid Subtropical Climate).