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Rab escort protein 1

CHM
Identifiers
Aliases CHM, DXS540, GGTA, HSD-32, REP-1, TCD, Rab escort protein 1
External IDs MGI: 892979 HomoloGene: 334 GeneCards: CHM
RNA expression pattern
PBB GE CHM 207099 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000390
NM_001037312
NM_001145414
NM_001320959

NM_018818

RefSeq (protein)

NP_000381
NP_001138886
NP_001307888

n/a

Location (UCSC) Chr X: 85.86 – 86.05 Mb Chr X: 113.04 – 113.19 Mb
PubMed search

NM_000390
NM_001037312
NM_001145414
NM_001320959

NM_018818

NP_000381
NP_001138886
NP_001307888

n/a

Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane.


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Wikipedia

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