Rab escort protein

CHM
Identifiers
Aliases	CHM, DXS540, GGTA, HSD-32, REP-1, TCD, Rab escort protein 1
External IDs	MGI: 892979 HomoloGene: 334 GeneCards: CHM
Gene ontology Molecular function • Rab geranylgeranyltransferase activity • oxidoreductase activity • Rab GTPase binding • GTPase activator activity • GDP-dissociation inhibitor activity Cellular component • cytoplasm • Rab-protein geranylgeranyltransferase complex • cytosol Biological process • positive regulation of GTPase activity • intracellular protein transport • protein geranylgeranylation • oxidation-reduction process • response to stimulus • visual perception • protein targeting to membrane • regulation of catalytic activity • small GTPase mediated signal transduction • regulation of apoptotic process • membrane organization • post-translational protein modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1121	12662
Ensembl	ENSG00000188419	ENSMUSG00000025531
UniProt	P24386	Q9QXG2
RefSeq (mRNA)	NM_000390 NM_001037312 NM_001145414 NM_001320959	NM_018818
RefSeq (protein)	NP_000381 NP_001138886 NP_001307888	n/a
Location (UCSC)	Chr X: 85.86 – 86.05 Mb	Chr X: 113.04 – 113.19 Mb
PubMed search

1121

12662

ENSG00000188419

ENSMUSG00000025531

P24386

Q9QXG2

NM_000390
NM_001037312
NM_001145414
NM_001320959

NM_018818

NP_000381
NP_001138886
NP_001307888

n/a

Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene.

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane.

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