RYR2

RYR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4JKQ
Identifiers
Aliases	RYR2, ARVC2, ARVD2, RYR-2, RyR, VTSIP, ryanodine receptor 2
External IDs	MGI: 99685 HomoloGene: 37423 GeneCards: RYR2
Gene ontology Molecular function • ion channel binding • calcium channel activity • calcium-induced calcium release activity • protein kinase A catalytic subunit binding • organic cyclic compound binding • protein self-association • ion channel activity • protein binding • identical protein binding • enzyme binding • suramin binding • protein kinase A regulatory subunit binding • protein kinase binding • calcium-release channel activity • ryanodine-sensitive calcium-release channel activity • calcium ion binding • calmodulin binding Cellular component • integral component of membrane • calcium channel complex • membrane • sarcomere • junctional sarcoplasmic reticulum membrane • sarcoplasmic reticulum • protein complex • Z disc • sarcoplasmic reticulum membrane • extracellular exosome • smooth endoplasmic reticulum • plasma membrane Biological process • response to muscle stretch • cytosolic calcium ion transport • release of sequestered calcium ion into cytosol • calcium ion transport into cytosol • regulation of cardiac conduction • regulation of cardiac muscle contraction by calcium ion signaling • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • response to hypoxia • cardiac muscle contraction • regulation of cytosolic calcium ion concentration • positive regulation of the force of heart contraction • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • cardiac muscle hypertrophy • ventricular cardiac muscle cell action potential • cell communication by electrical coupling involved in cardiac conduction • cellular calcium ion homeostasis • establishment of protein localization to endoplasmic reticulum • ion transport • BMP signaling pathway • left ventricular cardiac muscle tissue morphogenesis • regulation of heart rate • positive regulation of heart rate • detection of calcium ion • response to redox state • cellular response to epinephrine stimulus • multicellular organism development • ion transmembrane transport • positive regulation of sequestering of calcium ion • embryonic heart tube morphogenesis • calcium ion transmembrane transport • cellular response to caffeine • sarcoplasmic reticulum calcium ion transport • transport • canonical Wnt signaling pathway • regulation of SA node cell action potential • response to caffeine • regulation of cardiac muscle contraction • regulation of ventricular cardiac muscle cell action potential • regulation of AV node cell action potential • calcium-mediated signaling using intracellular calcium source • response to muscle activity • calcium ion transport • calcium-mediated signaling • type B pancreatic cell apoptotic process • regulation of atrial cardiac muscle cell action potential • positive regulation of calcium-transporting ATPase activity • Purkinje myocyte to ventricular cardiac muscle cell signaling • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6262	20191
Ensembl	ENSG00000198626	ENSMUSG00000021313
UniProt	Q92736	E9Q401
RefSeq (mRNA)	NM_001035	NM_023868
RefSeq (protein)	NP_001026	NP_076357.2 NP_076357
Location (UCSC)	Chr 1: 237.04 – 237.83 Mb	Chr 13: 11.55 – 12.11 Mb
PubMed search

4JKQ

6262

20191

ENSG00000198626

ENSMUSG00000021313

Q92736

E9Q401

NM_001035

NM_023868

NP_001026

NP_076357.2
NP_076357

Ryanodine receptor 2 (RYR2) is a protein found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major mediator for sarcoplasmic release of stored calcium ions.

The channel is composed of RYR2 homotetramers and FK506-binding proteins found in a 1:4 stoichiometric ratio. Calcium channel function is affected by the specific type of FK506 isomer interacting with the RYR2 protein, due to binding differences and other factors.

The RYR2 protein functions as the major component of a calcium channel located in the sarcoplasmic reticulum that supplies ions to the cardiac muscle during systole. To enable cardiac muscle contraction, calcium influx through voltage-gated L-type calcium channels in the plasma membrane allows calcium ions to bind to RYR2 located on the sarcoplasmic reticulum. This binding causes the release of calcium through RYR2 from the sarcoplasmic reticulum into the cytosol, where it binds to the C domain of troponin, which shifts tropomyosin and allows the myosin ATPase to bind to actin, enabling cardiac muscle contraction. RYR2 channels are associated with many cellular functions, including mitochondrial metabolism, gene expression and cell survival, in addition to their role in cardiomyocyte contraction.

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