RUNX2

RUNX2
Identifiers
Aliases	RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, runt related transcription factor 2
External IDs	OMIM: 600211 MGI: 99829 HomoloGene: 68389 GeneCards: RUNX2
Gene ontology Molecular function • DNA binding • protein domain specific binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • bHLH transcription factor binding • protein binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • repressing transcription factor binding • ATP binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • cytoplasm • transcription factor complex • nucleoplasm • nuclear chromatin • nucleus Biological process • skeletal system development • hemopoiesis • regulation of transcription, DNA-templated • negative regulation of smoothened signaling pathway • chondrocyte differentiation • ossification • regulation of transcription from RNA polymerase II promoter • regulation of fibroblast growth factor receptor signaling pathway • skeletal system morphogenesis • chondrocyte development • cellular response to BMP stimulus • endochondral ossification • regulation of odontogenesis of dentin-containing tooth • cell maturation • transcription from RNA polymerase II promoter • BMP signaling pathway • stem cell differentiation • transcription, DNA-templated • odontogenesis of dentin-containing tooth • T cell differentiation • positive regulation of gene expression • positive regulation of osteoblast differentiation • regulation of osteoblast differentiation • positive regulation of chondrocyte differentiation • osteoblast differentiation • neuron differentiation • positive regulation of cell proliferation • regulation of cell differentiation • osteoblast development • embryonic cranial skeleton morphogenesis • regulation of ossification • embryonic forelimb morphogenesis • positive regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • osteoblast fate commitment • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	860	12393
Ensembl	ENSG00000124813	ENSMUSG00000039153
UniProt	Q13950	Q08775
RefSeq (mRNA)	NM_001015051 NM_001024630 NM_001278478 NM_004348	NM_001145920 NM_001146038 NM_001271627 NM_001271630 NM_001271631 NM_001271633 NM_009820
RefSeq (protein)	NP_001015051 NP_001019801 NP_001265407	NP_001139510.1 NP_001258556.1 NP_033950.2 NP_001139392 NP_001139510 NP_001258556 NP_001258559 NP_001258560 NP_033950
Location (UCSC)	Chr 6: 45.33 – 45.66 Mb	Chr 17: 44.5 – 44.81 Mb
PubMed search

860

12393

ENSG00000124813

ENSMUSG00000039153

Q13950

Q08775

NM_001015051
NM_001024630
NM_001278478
NM_004348

NM_001271633
NM_009820

NP_001015051
NP_001019801
NP_001265407

NP_001258556
NP_001258559
NP_001258560
NP_033950

Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation.

...
Wikipedia