RPTOR

RPTOR
Identifiers
Aliases	RPTOR, KOG1, Mip1, regulatory associated protein of MTOR complex 1
External IDs	MGI: 1921620 HomoloGene: 80210 GeneCards: RPTOR
Gene ontology Molecular function • RNA polymerase III type 2 promoter DNA binding • 14-3-3 protein binding • protein complex binding • RNA polymerase III type 3 promoter DNA binding • RNA polymerase III type 1 promoter DNA binding • TFIIIC-class transcription factor binding • protein binding • protein kinase binding • protein binding, bridging • protein kinase activator activity • protein serine/threonine kinase inhibitor activity Cellular component • lysosomal membrane • cytoplasm • TORC1 complex • neuronal cell body • dendrite • nucleoplasm • cytosol • cytoplasmic stress granule • lysosome Biological process • positive regulation of protein serine/threonine kinase activity • positive regulation of endothelial cell proliferation • regulation of phosphorylation • positive regulation of TOR signaling • cellular response to nutrient levels • cell cycle arrest • TOR signaling • cellular response to amino acid stimulus • regulation of cell size • cell growth • positive regulation of transcription from RNA polymerase III promoter • regulation of cellular response to heat • activation of protein kinase activity • cellular response to starvation • regulation of autophagy • positive regulation of peptidyl-threonine phosphorylation • positive regulation of cell growth • positive regulation of peptidyl-serine phosphorylation • TORC1 signaling • negative regulation of protein serine/threonine kinase activity • positive regulation of G1/S transition of mitotic cell cycle • regulation of macroautophagy • cellular response to leucine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57521	74370
Ensembl	ENSG00000141564	ENSMUSG00000025583
UniProt	Q8N122	Q8K4Q0
RefSeq (mRNA)	NM_020761 NM_001163034	NM_028898 NM_001306081
RefSeq (protein)	NP_001156506 NP_065812	n/a
Location (UCSC)	Chr 17: 80.54 – 80.97 Mb	Chr 11: 119.6 – 119.9 Mb
PubMed search

57521

74370

ENSG00000141564

ENSMUSG00000025583

Q8N122

Q8K4Q0

NM_020761
NM_001163034

NM_028898
NM_001306081

NP_001156506
NP_065812

n/a

Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTOR gene. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.

The human gene is located on human chromosome 17 with location of the cytogenic band at 17q25.3.

RPTOR is highly expressed in skeletal muscle and is somewhat less present in brain, lung, small intestine, kidney, and placenta tissue. Isoform 3 is widely expressed and most highly expressed in the nasal mucosa and pituitary. The lowest levels occur in the spleen. In the cell, RPTOR is present in cytoplasm, lysosomes, and cytoplasmic granules. Amino acid availability determines RPTOR targeting to lysosomes. In stressed cells, RPTOR associates with SPAG5 and accumulates in stress granules, which significantly reduces its presence in lysosomes...

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Wikipedia