RPTN

RPTN
Identifiers
Aliases	RPTN, Repetin
External IDs	MGI: 1099055 HomoloGene: 84780 GeneCards: RPTN
Gene ontology Molecular function • metal ion binding • calcium ion binding • transition metal ion binding Cellular component • proteinaceous extracellular matrix • extracellular region • cytosol • cornified envelope Biological process • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	126638	20129
Ensembl	ENSG00000215853	ENSMUSG00000041984
UniProt	Q6XPR3	P97347
RefSeq (mRNA)	NM_152364 NM_001122965	NM_009100
RefSeq (protein)	NP_001116437	NP_033126
Location (UCSC)	Chr 1: 152.15 – 152.16 Mb	Chr 3: 93.39 – 93.4 Mb
PubMed search

126638

20129

ENSG00000215853

ENSMUSG00000041984

Q6XPR3

P97347

NM_152364
NM_001122965

NM_009100

NP_001116437

NP_033126

Repetin is an extracellular matrix protein expressed in the epidermis. In humans it is encoded by the RPTN gene. Repetin is part of the S100 fused-type protein family and contains a EF hand structural domain.

RPTN is one of the genes that differ between present-day humans and Neanderthals. It functions in the cornified cell envelope formation. It is a multifunctional epidermal matrix protein. RPTN reversibly binds calcium.

RPTN is 5,634 bases long. It starts 152,126,071 base pairs from pter. It ends 152,131,704 base pairs from pter. It has a minus strand orientation.

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Wikipedia