ROR1

ROR1
Identifiers
Aliases	ROR1, NTRKR1, dJ537F10.1, receptor tyrosine kinase-like orphan receptor 1, receptor tyrosine kinase like orphan receptor 1
External IDs	MGI: 1347520 HomoloGene: 3675 GeneCards: ROR1
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase activity • nucleotide binding • protein binding • protein kinase activity • Wnt-protein binding • kinase activity • ATP binding • transferase activity • coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Cellular component • receptor complex • integral component of plasma membrane • integral component of membrane • membrane • plasma membrane • stress fiber • cytoplasm • cell surface Biological process • phosphorylation • protein phosphorylation • Wnt signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • Wnt signaling pathway, planar cell polarity pathway • peptidyl-tyrosine phosphorylation • astrocyte development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4919	26563
Ensembl	ENSG00000185483	ENSMUSG00000035305
UniProt	Q01973	Q9Z139
RefSeq (mRNA)	NM_001083592 NM_005012	NM_013845 NM_001312690
RefSeq (protein)	NP_001077061 NP_005003	NP_001299619.1 NP_038873.2 NP_001299619 NP_038873
Location (UCSC)	Chr 1: 63.77 – 64.18 Mb	Chr 4: 100.1 – 100.44 Mb
PubMed search

4919

26563

ENSG00000185483

ENSMUSG00000035305

Q01973

Q9Z139

NM_001083592
NM_005012

NM_013845
NM_001312690

NP_001077061
NP_005003

NP_001299619.1
NP_038873.2
NP_001299619
NP_038873

Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene. ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. ROR1 is currently under investigation for its role in the metastasis of cancer cells.

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Wikipedia