RFC5

RFC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LFS
Identifiers
Aliases	RFC5, RFC36, replication factor C subunit 5
External IDs	MGI: 1919401 HomoloGene: 6730 GeneCards: RFC5
Gene ontology Molecular function • nucleotide binding • DNA binding • single-stranded DNA-dependent ATPase activity • protein binding • ATP binding • enzyme binding • DNA clamp loader activity Cellular component • DNA replication factor C complex • Ctf18 RFC-like complex • nucleoplasm • nucleus Biological process • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • error-prone translesion synthesis • telomere maintenance via recombination • positive regulation of DNA-directed DNA polymerase activity • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • DNA damage response, detection of DNA damage • nucleotide-excision repair, DNA incision, 5'-to lesion • DNA repair • DNA replication • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5985	72151
Ensembl	ENSG00000111445	ENSMUSG00000029363
UniProt	P40937	Q9D0F6
RefSeq (mRNA)	NM_001130112 NM_001130113 NM_001206801 NM_007370 NM_181578 NM_001346815	NM_028128
RefSeq (protein)	NP_001123584 NP_001123585 NP_001193730 NP_001333744 NP_031396 NP_853556	NP_082404.1 NP_082404
Location (UCSC)	Chr 12: 118.01 – 118.03 Mb	Chr 5: 117.38 – 117.39 Mb
PubMed search

1LFS

5985

72151

ENSG00000111445

ENSMUSG00000029363

P40937

Q9D0F6

NM_001346815

NM_028128

NP_853556

NP_082404.1
NP_082404

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

RFC5 has been shown to interact with:

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Wikipedia