RFC4

RFC4
Identifiers
Aliases	RFC4, A1, RFC37, replication factor C subunit 4
External IDs	MGI: 2146571 HomoloGene: 6288 GeneCards: RFC4
Gene ontology Molecular function • nucleotide binding • DNA binding • single-stranded DNA-dependent ATPase activity • protein binding • enzyme binding • ATP binding • DNA clamp loader activity Cellular component • DNA replication factor C complex • Ctf18 RFC-like complex • nucleoplasm • nucleus Biological process • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • DNA strand elongation involved in DNA replication • error-prone translesion synthesis • DNA replication • telomere maintenance via recombination • positive regulation of DNA-directed DNA polymerase activity • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • DNA damage response, detection of DNA damage • regulation of signal transduction by p53 class mediator • nucleotide-excision repair, DNA incision, 5'-to lesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5984	106344
Ensembl	ENSG00000163918	ENSMUSG00000022881
UniProt	P35249	Q99J62
RefSeq (mRNA)	NM_181573 NM_002916	NM_145480
RefSeq (protein)	NP_002907 NP_853551	NP_663455.1 NP_663455
Location (UCSC)	Chr 3: 186.79 – 186.81 Mb	Chr 16: 23.11 – 23.13 Mb
PubMed search

5984

106344

ENSG00000163918

ENSMUSG00000022881

P35249

Q99J62

NM_181573
NM_002916

NM_145480

NP_002907
NP_853551

NP_663455.1
NP_663455

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.

RFC4 has been shown to interact with:

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Wikipedia