RFC3

RFC3
Identifiers
Aliases	RFC3, RFC38, replication factor C subunit 3
External IDs	MGI: 1916513 HomoloGene: 2188 GeneCards: RFC3
Gene ontology Molecular function • single-stranded DNA-dependent ATPase activity • ATPase activity • protein binding • DNA binding • DNA clamp loader activity Cellular component • Ctf18 RFC-like complex • nucleoplasm • DNA replication factor C complex • nucleus Biological process • DNA damage response, detection of DNA damage • nucleotide-excision repair, DNA gap filling • DNA synthesis involved in DNA repair • error-free translesion synthesis • DNA strand elongation involved in DNA replication • error-prone translesion synthesis • positive regulation of DNA-directed DNA polymerase activity • response to organophosphorus • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • DNA replication • nucleotide-excision repair, DNA incision, 5'-to lesion • regulation of signal transduction by p53 class mediator • telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5983	69263
Ensembl	ENSG00000133119	ENSMUSG00000033970
UniProt	P40938	Q8R323
RefSeq (mRNA)	NM_002915 NM_181558	NM_027009
RefSeq (protein)	NP_002906 NP_853536	NP_081285
Location (UCSC)	Chr 13: 33.82 – 33.97 Mb	Chr 5: 151.64 – 151.65 Mb
PubMed search

5983

69263

ENSG00000133119

ENSMUSG00000033970

P40938

Q8R323

NM_002915
NM_181558

NM_027009

NP_002906
NP_853536

NP_081285

Replication factor C subunit 3 is a protein that in humans is encoded by the RFC3 gene.

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described.

RFC3 has been shown to interact with:

...
Wikipedia