RFC2

RFC2
Identifiers
Aliases	RFC2, RFC40, replication factor C subunit 2
External IDs	MGI: 1341868 HomoloGene: 6885 GeneCards: RFC2
Gene ontology Molecular function • nucleotide binding • DNA binding • single-stranded DNA-dependent ATPase activity • protein binding • enzyme binding • ATP binding • DNA clamp loader activity Cellular component • DNA replication factor C complex • Ctf18 RFC-like complex • nucleoplasm • nucleus Biological process • nucleotide-excision repair, DNA gap filling • error-free translesion synthesis • error-prone translesion synthesis • DNA replication • telomere maintenance via recombination • positive regulation of DNA-directed DNA polymerase activity • translesion synthesis • transcription-coupled nucleotide-excision repair • nucleotide-excision repair, DNA incision • DNA damage response, detection of DNA damage • regulation of signal transduction by p53 class mediator • nucleotide-excision repair, DNA incision, 5'-to lesion • DNA repair Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5982	19718
Ensembl	ENSG00000049541	ENSMUSG00000023104
UniProt	P35250 Q75MT5	Q9WUK4
RefSeq (mRNA)	NM_001278791 NM_001278792 NM_001278793 NM_002914 NM_181471	NM_020022
RefSeq (protein)	NP_001265720 NP_001265721 NP_001265722 NP_002905 NP_852136 NP_002905.2	NP_064406.1 NP_064406
Location (UCSC)	Chr 7: 74.23 – 74.25 Mb	Chr 5: 134.58 – 134.6 Mb
PubMed search

5982

19718

ENSG00000049541

ENSMUSG00000023104

P35250
Q75MT5

Q9WUK4

NM_001278791
NM_001278792
NM_001278793
NM_002914
NM_181471

NM_020022

NP_002905.2

NP_064406.1
NP_064406

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.

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Wikipedia