RELA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22

Identifiers

Aliases

RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit

External IDs

OMIM: 164014 MGI: 103290 HomoloGene: 32064 GeneCards: RELA

Gene ontology
Molecular function	• protein N-terminus binding • transcription factor activity, sequence-specific DNA binding • protein complex binding • ankyrin repeat binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription regulatory region DNA binding • repressing transcription factor binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor binding • activating transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • enzyme binding • phosphate ion binding • RNA polymerase II distal enhancer sequence-specific DNA binding • protein homodimerization activity • chromatin binding • NF-kappaB binding • protein binding • protein kinase binding • DNA binding • sequence-specific DNA binding • actinin binding • identical protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin DNA binding • ubiquitin protein ligase binding • transcription factor activity, RNA polymerase II core promoter sequence-specific • core promoter sequence-specific DNA binding
Cellular component	• cytoplasm • cytosol • nucleus • I-kappaB/NF-kappaB complex • transcription factor complex • NF-kappaB complex • nucleoplasm • protein complex • nuclear chromatin
Biological process	• response to amino acid • response to interleukin-1 • cellular response to interleukin-6 • response to progesterone • response to organic substance • Fc-epsilon receptor signaling pathway • positive regulation of interleukin-12 biosynthetic process • negative regulation of insulin receptor signaling pathway • defense response to virus • positive regulation of chondrocyte differentiation • animal organ morphogenesis • response to muscle stretch • response to cytokine • regulation of transcription, DNA-templated • negative regulation of protein catabolic process • cytokine-mediated signaling pathway • negative regulation of extrinsic apoptotic signaling pathway • response to mechanical stimulus • response to muramyl dipeptide • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • response to insulin • negative regulation of NIK/NF-kappaB signaling • nucleotide-binding oligomerization domain containing 2 signaling pathway • membrane protein intracellular domain proteolysis • inflammatory response • viral process • response to cobalamin • hair follicle development • positive regulation of miRNA metabolic process • acetaldehyde metabolic process • cellular response to hepatocyte growth factor stimulus • cellular response to nicotine • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • cellular defense response • response to morphine • response to lipopolysaccharide • positive regulation of NF-kappaB transcription factor activity • cellular response to interleukin-1 • response to inorganic substance • regulation of inflammatory response • response to cAMP • negative regulation of transcription, DNA-templated • response to hydrogen peroxide • positive regulation of Schwann cell differentiation • defense response • response to bacterium • response to organic cyclic compound • cellular response to tumor necrosis factor • aging • cellular response to peptide hormone stimulus • positive regulation of cell proliferation • positive regulation of I-kappaB kinase/NF-kappaB signaling • liver development • response to UV-B • T cell receptor signaling pathway • cellular response to lipopolysaccharide • positive regulation of type I interferon production • response to drug • positive regulation of transcription from RNA polymerase II promoter • cellular response to hydrogen peroxide • transcription from RNA polymerase II promoter • positive regulation of pri-miRNA transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


5970


19697

Ensembl


ENSG00000173039


ENSMUSG00000024927

UniProt


Q04206


Q04207

RefSeq (mRNA)


NM_001145138 NM_001243984 NM_001243985 NM_021975


NM_009045

RefSeq (protein)


NP_001138610 NP_001230913 NP_001230914 NP_068810


NP_033071.1 NP_033071

Location (UCSC)

Chr 11: 65.65 – 65.66 Mb

Chr 19: 5.64 – 5.65 Mb

PubMed search

4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22

NM_001145138
NM_001243984
NM_001243985
NM_021975

NM_009045

NP_001138610
NP_001230913
NP_001230914
NP_068810

...
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