REL

Identifiers

REL, C-Rel, REL proto-oncogene, NF-kB subunit

External IDs

Gene ontology
Molecular function	• RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • chromatin binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • transcription factor activity, sequence-specific DNA binding
Cellular component	• cytoplasm • cytosol • I-kappaB/NF-kappaB complex • transcription factor complex • nucleoplasm • nucleus
Biological process	• response to cytokine • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • negative regulation of interferon-beta production • negative regulation of gene expression • transcription, DNA-templated • positive regulation of transcription, DNA-templated • NIK/NF-kappaB signaling • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • inflammatory response • positive regulation of transcription from RNA polymerase II promoter • negative regulation of neuron death • I-kappaB kinase/NF-kappaB signaling • transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5966


19696


ENSG00000162924


ENSMUSG00000020275


Q04864


P15307

RefSeq (mRNA)


NM_001291746 NM_002908


NM_009044

RefSeq (protein)


NP_001278675 NP_002899


NP_033070

Location (UCSC)

PubMed search

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.