RDBP

NELFE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5P, 2BZ2, 2JX2
Identifiers
Aliases	NELFE, D6S45, NELF-E, RD, RDBP, RDP, negative elongation factor complex member E
External IDs	MGI: 102744 HomoloGene: 134736 GeneCards: NELFE
Gene ontology Molecular function • nucleic acid binding • protein binding • chromatin binding • RNA binding Cellular component • nucleus • nucleoplasm • NELF complex • plasma membrane • nuclear body Biological process • negative regulation of transcription elongation from RNA polymerase II promoter • positive regulation of ERK1 and ERK2 cascade • positive regulation of viral transcription • transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of histone H3-K4 methylation • negative regulation of transcription from RNA polymerase II promoter • negative regulation of mRNA polyadenylation • transcription elongation from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7936	27632
Ensembl	ENSG00000229363 ENSG00000206357 ENSG00000231044 ENSG00000204356 ENSG00000206268 ENSG00000233801	ENSMUSG00000024369
UniProt	P18615	P19426
RefSeq (mRNA)	NM_002904	NM_001045863 NM_001045864 NM_138580
RefSeq (protein)	NP_002895	NP_001039328 NP_001039329 NP_613046
Location (UCSC)	Chr 6: 31.95 – 31.96 Mb	Chr 17: 34.85 – 34.86 Mb
PubMed search

1X5P, 2BZ2, 2JX2

7936

27632

ENSG00000233801

ENSMUSG00000024369

P18615

P19426

NM_002904

NM_001045863
NM_001045864
NM_138580

NP_002895

NP_001039328
NP_001039329
NP_613046

Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

...
Wikipedia