RBFOX1

RBFOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ERR, 4ZKA, 2N82
Identifiers
Aliases	RBFOX1, 2BP1, A2BP1, FOX-1, FOX1, HRNBP1, RNA binding protein, fox-1 homolog 1
External IDs	MGI: 1926224 HomoloGene: 69339 GeneCards: RBFOX1
Gene ontology Molecular function • protein C-terminus binding • protein binding • mRNA binding • RNA binding • nucleic acid binding Cellular component • cytoplasm • trans-Golgi network • nucleus Biological process • regulation of RNA splicing • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • RNA splicing • nervous system development • RNA transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54715	268859
Ensembl	ENSG00000078328	ENSMUSG00000008658
UniProt	Q9NWB1	Q9JJ43
RefSeq (mRNA)	NM_001142333 NM_001142334 NM_001308117 NM_018723 NM_145891 NM_145892 NM_145893	NM_021477 NM_183188
RefSeq (protein)	NP_001135805 NP_001135806 NP_001295046 NP_061193 NP_665898 NP_665899 NP_665900	NP_067452 NP_899011
Location (UCSC)	Chr 16: 6.02 – 7.71 Mb	Chr 16: 6.81 – 7.41 Mb
PubMed search

2ERR, 4ZKA, 2N82

54715

268859

ENSG00000078328

ENSMUSG00000008658

Q9NWB1

Q9JJ43

NM_145892
NM_145893

NM_021477
NM_183188

NP_665899
NP_665900

NP_067452
NP_899011

Fox-1 homolog A also known as ataxin 2-binding protein 1 (A2BP1) or hexaribonucleotide-binding protein 1 (HRNBP1) or RNA binding protein, fox-1 homolog (RBFOX1), is a protein that in humans is encoded by the RBFOX1 gene.

Ataxin 2-binding protein 1 has an RNA recognition motif that is highly conserved among RNA-binding proteins. This protein binds to the C-terminus of ataxin-2, and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the gene product of the SCA2 gene which causes familial neurodegenerative diseases. Several alternatively spliced transcript variants have been found for this gene. Some of these variants localize to the nucleus and some other to the cytoplasm. Nuclear variants have a well-established role in tissue specific alternative splicing. Rbfox1 cytoplasmic variants modulate mRNA stability and translation.

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Wikipedia