RBBP7

RBBP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CFS, 3CFV
Identifiers
Aliases	RBBP7, RbAp46, retinoblastoma binding protein 7, RB binding protein 7, chromatin remodeling factor
External IDs	MGI: 1194910 HomoloGene: 55702 GeneCards: RBBP7
Gene ontology Molecular function • protein binding • RNA binding • histone deacetylase activity Cellular component • NuRD complex • ESC/E(Z) complex • nucleus • nucleoplasm • cytosol Biological process • regulation of transcription, DNA-templated • response to steroid hormone • cellular heat acclimation • negative regulation of transcription from RNA polymerase II promoter • CENP-A containing nucleosome assembly • transcription, DNA-templated • multicellular organism development • DNA replication • negative regulation of gene expression, epigenetic • negative regulation of cell growth • cell proliferation • negative regulation of transcription, DNA-templated • regulation of signal transduction by p53 class mediator • histone deacetylation • covalent chromatin modification • post-translational protein modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5931	245688
Ensembl	ENSG00000102054	ENSMUSG00000031353
UniProt	Q16576	Q60973
RefSeq (mRNA)	NM_001198719 NM_002893	NM_009031
RefSeq (protein)	NP_001185648 NP_002884	NP_033057.3 NP_033057
Location (UCSC)	Chr X: 16.84 – 16.87 Mb	Chr X: 162.76 – 162.78 Mb
PubMed search

3CFS, 3CFV

5931

245688

ENSG00000102054

ENSMUSG00000031353

Q16576

Q60973

NM_001198719
NM_002893

NM_009031

NP_001185648
NP_002884

NP_033057.3
NP_033057

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.

...
Wikipedia