RASA1

RASA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WER, 1WQ1, 2GQI, 2J05, 2J06, 2M51, 4FSS, 2GSB
Identifiers
Aliases	RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP, RAS p21 protein activator 1, p120
External IDs	MGI: 97860 HomoloGene: 2168 GeneCards: RASA1
Gene ontology Molecular function • potassium channel inhibitor activity • protein binding • GTPase binding • receptor binding • GTPase activator activity • phosphotyrosine residue binding • GTPase activity Cellular component • cytoplasm • cytosol • intrinsic component of the cytoplasmic side of the plasma membrane • ruffle • plasma membrane Biological process • negative regulation of neuron apoptotic process • negative regulation of cell adhesion • intracellular signal transduction • blood vessel morphogenesis • embryo development • ephrin receptor signaling pathway • regulation of GTPase activity • mitotic cytokinesis • MAPK cascade • negative regulation of Ras protein signal transduction • negative regulation of cell-matrix adhesion • vasculogenesis • regulation of actin filament polymerization • positive regulation of GTPase activity • regulation of RNA metabolic process • regulation of cell shape • signal transduction • negative regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5921	218397
Ensembl	ENSG00000145715	ENSMUSG00000021549
UniProt	P20936	E9PYG6
RefSeq (mRNA)	NM_002890 NM_022650	NM_145452
RefSeq (protein)	NP_002881 NP_072179	NP_663427
Location (UCSC)	Chr 5: 87.27 – 87.39 Mb	Chr 13: 85.21 – 85.29 Mb
PubMed search

1WER, 1WQ1, 2GQI, 2J05, 2J06, 2M51, 4FSS, 2GSB

5921

218397

ENSG00000145715

ENSMUSG00000021549

P20936

E9PYG6

NM_002890
NM_022650

NM_145452

NP_002881
NP_072179

NP_663427

RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

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Wikipedia