RAR-related orphan receptor alpha

RORA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1N83, 1S0X, 4S15

Identifiers

Aliases

RORA, NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA, RAR related orphan receptor A

External IDs

OMIM: 600825 MGI: 104661 HomoloGene: 56594 GeneCards: RORA

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • beta-catenin binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, direct ligand regulated sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcription factor binding • metal ion binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • core promoter sequence-specific DNA binding • protein binding • transcription coactivator binding • transcription corepressor binding • oxysterol binding
Cellular component	• nucleoplasm • nucleus
Biological process	• regulation of cholesterol homeostasis • negative regulation of fat cell differentiation • nitric oxide biosynthetic process • regulation of transcription, DNA-templated • cGMP metabolic process • rhythmic process • cellular response to sterol • cellular response to tumor necrosis factor • cerebellar Purkinje cell differentiation • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • transcription, DNA-templated • cerebellar granule cell precursor proliferation • regulation of steroid metabolic process • positive regulation of transcription, DNA-templated • regulation of smoothened signaling pathway • muscle cell differentiation • intracellular receptor signaling pathway • regulation of glucose metabolic process • regulation of transcription involved in cell fate commitment • regulation of circadian rhythm • angiogenesis • cellular response to interleukin-1 • xenobiotic metabolic process • positive regulation of circadian rhythm • positive regulation of vascular endothelial growth factor production • T-helper 17 cell differentiation • transcription initiation from RNA polymerase II promoter • negative regulation of inflammatory response • cellular response to hypoxia • triglyceride homeostasis • regulation of macrophage activation • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • circadian rhythm
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6095


19883

Ensembl


ENSG00000069667


ENSMUSG00000032238

UniProt


P35398


P51448

RefSeq (mRNA)


NM_002943 NM_134260 NM_134261 NM_134262


NM_013646 NM_001289916 NM_001289917

RefSeq (protein)


NP_002934 NP_599022 NP_599023 NP_599024


NP_001276845.1 NP_038674.1 NP_001276845 NP_001276846 NP_038674

Location (UCSC)

Chr 15: 60.49 – 61.23 Mb

Chr 9: 68.65 – 69.39 Mb

PubMed search

1N83, 1S0X, 4S15

NM_002943
NM_134260
NM_134261
NM_134262

NM_013646
NM_001289916
NM_001289917

NP_002934
NP_599022
NP_599023
NP_599024

NP_001276845.1
NP_038674.1
NP_001276845
NP_001276846
NP_038674

...
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